PRF, or platelet-rich fibrin, is the next generation treatment of platelet concentrate. PRF is a fibrin matrix comprised of platelet cytokines, growth factors, and cells used to help promote skin rejuvenation, hair growth and wound healing.

Platelet-rich fibrin, or PRF, is a completely natural aesthetic injectable that can rejuvenate the appearance of your face.

Platelet-rich fibrin, or PRF, is a completely natural aesthetic injectable that can rejuvenate the appearance of your face. Using the concentration of your blood (PRF), you can restore a more youthful, smooth appearance for many patients.

The injections also continue to work overtime, therefore promoting the generation of new collagen. This treatment is best done in a series to achieve the best results. Patients may also choose to do a combination of hyaluronic acid filler mixed with PRF to get an even better result.

A small amount of blood is drawn and then placed in the PRF centrifuge. The PRF is spun at a lower speed necessary to keep white blood cells and stem cells together with the blood platelets and plasma. The PRF is then extracted and ready for injection.

PRF works on a simple premise, utilizing your natural platelets to instruct the body to create new collagen for tighter, smoother, and better-toned skin.


Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are similar in their premise and application but differ in how the effects are achieved. For quite a while, PRP dominated as the only viable platelet-based therapy for regeneration. But in recent years, PRF has proven to be as effective as PRP, if not better.

There’s a general consensus amongst the medical community that PRF has a distinct edge over PRP. Here are some of the reasons why PRF is better than PRP:

  • Due to the lack of adding coagulants, the preparation process of PRF is more straightforward and less convoluted. It also has the advantage of not using external additives to manipulate the concentration.
  • The higher concentration of platelets (about 3 to 5 times) of PRF makes it a more potent solution.
  • PRP has more stem cells, healing factors, and has a reduced risk of blood cells experiencing trauma or damage.


PRF should be considered if looking for a natural procedure to stimulate collagen or regrow thinning hair that uses no manmade products.

Platelet-rich fibrin can be used instead of traditional undereye filler or in addition to lessen dark circles and fill hollowness.

One benefit to PRF, platelet-rich fibrin versus PRP is that you do not have to draw as much blood. PRP requires more blood to be taken than PRF and newer research shows that a higher platelet concentration along with an increased number of white blood cells and stem cells, has more healing factors than traditional platelet-rich plasma. The use of PRF uses one’s growth factors to help regenerate collagen and reverse the signs of aging. The PRF releases slower and therefore adds an even longer anti-aging effect.


The areas of the face that can be injected with PRF include but are not limited to cheeks, tear troughs, nasolabial folds, the jawline, chin, and scalp for hair regrowth.

We offer FREE consultations at Dontage, talk to your provider at your next appointment with us to see if PRF or PRF EZ Gel is a treatment option for you!